Journal
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
Volume 40, Issue 6, Pages 492-494Publisher
WILEY-BLACKWELL
DOI: 10.1111/iji.12071
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Funding
- IRCCS 'Burlo Garofolo' (Trieste, Italy) [RC 07/08]
- Brazilian Minister for Sciences and Technology/CNPq [311949/2011-8]
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TREX-1 is a restriction factor against HIV-1. The coding sequence of TREX1 gene was analysed in HIV+ subjects searching for genetic variations possibly associated with the susceptibility to HIV infection. The single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX-1 in the anti-HIV response.
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