Journal
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
Volume 38, Issue 1, Pages 17-20Publisher
WILEY
DOI: 10.1111/j.1744-313X.2010.00972.x
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P>In the present work, we established a rapid, cost-effective and high-throughput method for genotyping using a multiplexed microsphere-based suspension array platform - Luminex (R) x MAP (TM), which enabled us to analyse two SNPs in the promoter of IL-6 gene, determining haplotypes associated with different levels of expression. Using this system, IL-6 diversity in four different ethnic groups - East Asians, Caucasians, Hispanic and African Americans - was assessed. Results showed a significant variability in terms of allele, genotype and haplotype distribution. Considering the important immunoregulatory role of this cytokine and as a clinically relevant marker, this genotyping approach will provide a powerful tool for disease association or transplant outcome studies.
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