Journal
INTERNATIONAL JOURNAL OF HYPERTHERMIA
Volume 28, Issue 6, Pages 509-517Publisher
INFORMA HEALTHCARE
DOI: 10.3109/02656736.2012.695427
Keywords
DNA double-strand breaks; heat-shock protein inhibitors; homologous recombination; hyperthermia; PARP inhibitors
Funding
- European Community [HEALTH-F2-2010-259893]
- Netherlands Organisation for Scientific Research (NWO)
- Netherlands Genomics Initiative/NWO
Ask authors/readers for more resources
Local hyperthermia is an effective treatment modality to augment radio-and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available