Journal
INTERNATIONAL JOURNAL OF HYPERTHERMIA
Volume 25, Issue 8, Pages 655-660Publisher
INFORMA HEALTHCARE
DOI: 10.3109/02656730903039605
Keywords
hyperthermia; mild electrical stimulation; low-intensity current; heat shock; Hsp72
Funding
- Ministry of Education, Science, Sports and Culture (MEXT) of Japan
- MEXT
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This review discusses the basic concepts, effects and applications of hyperthermia and mild electrical stimulation (MES) using low-intensity direct current. It also proposes a novel combinatorial use of MES and hyperthermia, and briefly outlines the rationale and the effects of MES and hyperthermia combination treatment on certain diseases (diabetes, hepatic ischaemia/reperfusion injury and gastric ulcer). The integrated modalities of MES and hyperthermia might find therapeutic applications to stress-induced diseases and intractable diseases of dysregulated signalling pathways.
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