Journal
INTERNATIONAL JOURNAL OF HYPERTHERMIA
Volume 24, Issue 1, Pages 79-90Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02656730701840147
Keywords
hyperthermia; liposome; imaging; MRI; PET; chemodosimetry; dose painting; drug delivery; nanoparticle
Funding
- NATIONAL CANCER INSTITUTE [P01CA042745] Funding Source: NIH RePORTER
- NCI NIH HHS [P01 CA042745, CA42745, P01 CA042745-22] Funding Source: Medline
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The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.
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