Journal
MICROFLUIDICS AND NANOFLUIDICS
Volume 19, Issue 1, Pages 9-18Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10404-014-1542-4
Keywords
3D printing; Soft lithography; One-step molding; 3D microfluidic chip; PDMS
Funding
- Hong Kong Research Grants Council [605210, 604712, CUHK4/CRF/12G]
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In this work, we developed a convenient, one-step soft-lithographic-based molding technique for molding truly 3D microfluidic channels in polydimethylsiloxane (PDMS) by overcoming two grand challenges. We optimized the post-treatment conditions for 3D-printed resin structures to facilitate the use of them as masters for PDMS replica molding. What is more important, we demonstrated a novel method for single-step molding from 3D-printed microstructures to generate truly 3D microfluidic networks easily. With this technique, we fabricated some key, functional 3D microfluidic structures and components including a basket-weaving network, a 3D chaotic advective mixer and microfluidic peristaltic valves. Furthermore, an interesting injection-on-demand microfluidic device was also demonstrated. Our technique offers a simple, fast route to the fabrication of 3D microfluidic chips in a short time without clean-room facilities.
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