Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 94, Issue 4, Pages 334-343Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12185-011-0949-x
Keywords
Osteoclast; Osteoblast; Angiogenesis; Myeloma niche
Categories
Funding
- Ministry of Education, Culture, Science and Sports of Japan
- Ministry of Health, Labor and Welfare of Japan
- National Cancer Center
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Cellular interplay in the bone marrow (BM) microenvironment in multiple myeloma (MM) mediates MM growth and the formation of bone-destructive lesions. MM cells show enhanced osteoclastogenesis, and stimulate angiogenesis in concert with BM stromal cells and osteoclasts, whereas they suppress osteoblastic differentiation, leading to devastating bone destruction and the rapid loss of bone. Importantly, osteoclasts, vascular endothelial cells, and BM stromal cells with defective osteoblastic differentiation create a cellular microenvironment suitable for MM growth and survival and confer a drug resistance to MM cells, which can be construed as the MM niche. Therefore, the MM niche must be targeted and disrupted to improve the efficacy of anti-tumor treatment and prevent the progression of bone disease in MM. Clarifying molecular mechanisms leading to the formation of the MM niche along with bone disease will help in the development of novel approaches targeting the interplay between MM cells and the BM microenvironment.
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