Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 92, Issue 1, Pages 136-143Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12185-010-0627-4
Keywords
Ellagic acid; Acute myeloid leukemia cells; Apoptosis; Caspase; Differentiation; ATRA
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Funding
- Japan Society for the Promotion of Science [18591091]
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [18591091] Funding Source: KAKEN
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All-trans retinoic acid (ATRA) is a standard drug used for differentiation therapy in acute promyelocytic leukemia. To potentiate this therapy, we examined the effect of ellagic acid (EA), a natural polyphenolic compound with antiproliferative and antioxidant properties, on the growth and differentiation of HL-60 acute myeloid leukemia cells. EA was found to induce apoptosis, which was blocked by pan-caspase inhibitor, Z-VAD-FMK. EA activated the caspase-3 pathway and enhanced the expressions of myeloid differentiation markers (CD11b, MRP-14 protein, granulocytic morphology) induced by ATRA treatment. These results indicate that EA is a potent apoptosis inducer and also effectively potentiates ATRA-induced myeloid differentiation of HL-60 cells.
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