Journal
MICROCHIMICA ACTA
Volume 182, Issue 11-12, Pages 2001-2007Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-015-1521-9
Keywords
Reduced graphene oxide; Octahedral tin oxide; Electrochemical determination; Differential pulse voltammetry; Dopamine
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Funding
- National Natural Science Foundation of China [21305122]
- Natural Science Foundation of Jiangsu Province [BK20131218]
- Opening Foundation of the State Key Laboratory of Analytical Chemistry for Life Science of Nanjing University [SKLACLS1312]
- Industry-University-Research Cooperative Innovation Foundation of Jiangsu Province [BY2014108-19, BY2014108-08]
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Novel nanocomposites were prepared from graphene oxide (GO) and octahedral tin dioxide (SnO2) through a facile process that included synthesis of octahedral SnO2 and the reduction of GO with ascorbic acid. The morphology and structure of the nanocomposites were characterized by UV-vis spectroscopy, transmission electron microscopy, and Raman spectroscopy. The nanocomposites were placed on a glassy carbon electrode where they displayed excellent performance in terms of differential pulse voltammetric determination of dopamine (DA). This is attributed to (a) the synergetic interactions between reduced graphene oxide (r-GO) and octahedral SnO2, and (b) the presence of a large number of active sites on the nanocomposites surface. The sensor responds to DA in the concentration range of 0.08 to 30 mu M, with a 6 nM detection limit if operated at 0.24 V (vs. Ag/AgCl). The modified electrode also widely suppresses the background current resulting from excess ascorbic acid and uric acids. The method was applied to the determination of DA in spiked human urine and gave satisfactory results, with recoveries in the range from 96.4 to 98.2 %.
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