Journal
MICROCHIMICA ACTA
Volume 183, Issue 2, Pages 799-804Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-015-1711-5
Keywords
Anti-inflammatory drug; Urine analysis; Multi-walled carbon nanotubes; HLB sorbent; Strong cation exchange chromatography; SCX; Nanomaterial
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Funding
- National Natural Science Foundation of China [21575033]
- Natural Science Foundation of Hebei Province [B2015201132, B2014201089]
- Technology Foundation for Selected Overseas Scholar [C201400301]
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A rapid method for solid-phase extraction (SPE) and quantitation of the non-steroidal anti-inflammatory drugs indometacin and acemetacin in urine was developed. SPE is based in of the use of a reduced graphene oxide (rGO) in a pipette tip, and separation and quantitation is based on HPLC with a Promosil C-18 column and UV detection. The amount of sorbent, types and volumes of washing solvent and elution solvent were optimized. The results showed that the use of the rGO sorbent and a miniaturized pipette tip cartridge are distinctly superior to other sorbents including multiwalled carbon nanotubes and conventional SPE cartridges. Linear responses to indometacin and acemetacin are found for the 0.1-50 mu g mL(-1) concentration ranges, recoveries (at three spiking levels) range from 89.6 % to 95.7 %, and the relative standard deviations are a parts per thousand currency sign6.4 %.
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