Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 59, Issue 3, Pages 152-159Publisher
WILEY
DOI: 10.1111/1348-0421.12227
Keywords
cytokines; enterovirus 71; hand; foot and mouth disease; meningoencephalitis
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Funding
- National Nature Science Foundation of China [81070004, 81000765, 81172692, 81373036]
- Key Project of Science and Technology of Zhejiang Province [2008C03003-1]
- Zhejiang Provincial Natural Science Foundation [LY12H2600]
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Enterovirus 71 (EV71) infection can cause severe neurological complications including meningoencephalitis (ME) in some patients with hand, foot and mouth disease (HFMD). However, to date no studies have reported changes in cytokine concentrations and their correlations with clinical variables in patients with ME following EV71 infection. In this study, responses of Th1/Th2 cytokine, including IL-2, IL-4, IL-6, IL-10, TNF- and IFN-, in cerebrospinal fluid (CSF) from patients with EV71-related HFMD with ME and patients with febrile convulsions (FC) were analyzed using cytometric bead array technology. It was found that CSF IL-6 and IFN- concentrations were significantly higher in patients with EV71-related ME than in those with FC. Additionally, both CSF IL-6 and IFN- concentrations were correlated with CSF cytology, fever duration and duration of hospital stay. More interestingly, a positive correlation between CSF IL-6 and IFN- concentrations was observed. Finally, receiver operating characteristic analysis revealed that when a cutoff value of 9.40pg/mL was set for IL-6, the sensitivity and specificity were 84.5% and 85.5%, respectively, for discriminating EV71-related ME from FC. In conclusion, IL-6 and IFN- may be associated with EV71-induced neuropathology.
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