Journal
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
Volume 103, Issue 3, Pages 232-236Publisher
WILEY
DOI: 10.1016/j.ijgo.2008.07.016
Keywords
Cervical cancer; Cervical intraepithelial neoplasia; Cryotherapy; Screening; Safety
Categories
Funding
- Bill & Melinda Gates Foundation through the Alliance for Cervical Cancer Prevention
Ask authors/readers for more resources
Objective: To evaluate the effectiveness, safety, and acceptability of cryotherapy for cervical intraepithelial neoplasia (CIN) when provided by trained midwives in rural India. Method: Women with colposcopic findings of CIN lesions suitable for ablative treatment received cryotherapy from trained midwives before the biopsy results were known. Cure rates, adverse effects, and complications were assessed and factors influencing cure rates were evaluated by chi(2) tests. Cure was defined as no clinical or histologic evidence of CIN lesions 6 or more months after treatment. Results: Of 1068 women treated with cryotherapy, 728 had histologically proven CIN in their pretreatment biopsy specimens; of the 574 reporting for follow-up, 538 (93.7%) were cured (95% confidence interval [CI], 92.1%-96.3%). Cure rates were 96.4% (95% Cl, 94.6%-98.1%) for CIN 1 and 82.1% (95% Cl, 74.7%-89.4%) for CIN 2 and CIN 3 lesions combined. Minor adverse effects were documented in 5.2% of the women. Conclusion: Cryotherapy provided by midwives was found to be safe, effective, and acceptable by the women. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available