Journal
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
Volume 33, Issue 6, Pages 581-591Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PGP.0000000000000095
Keywords
Fallopian tube; Immune system; Intraepithelial lymphocytes; Dendritic and NK cells; Digital microscopy
Categories
Funding
- Pathogenesis of Ovarian Serous Borderline Tumors NCI US National Cancer Institute [RO1 CA116184]
- US Department of Defense Elucidation of Molecular Alterations in Precursor Lesions of Ovarian Serous Carcinoma Consortium [OC100517]
- Ministero dell'Istruzione, dell'Universita e della Ricerca [2009CKARAL, 20104HBZ8E]
- Associazione Italiana per la Ricerca sul Cancro [AIRC IG 11924]
- Fondazione Beretta (Brescia, Italy)
- International Society of Gynecologic Pathologists Hernando Salazar Fellowship Award
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Recent studies implicating the fallopian tube as the site of putative precursors of ovarian serous carcinoma, and the hypothesis that injury, inflammation, and repair of the ovarian surface epithelium at the time of ovulation, may be contributing factors to ovarian carcinogenesis, prompted us to undertake a comprehensive analysis of the immune cells in the normal fallopian tube. Accordingly, the aim of this study was to provide a baseline for future studies exploring the relationship of inflammation with the early events of ovarian carcinogenesis by characterizing the immune cell repertoire in 13 normal human fallopian tubes, combining digital microscopy of immunostained slides and flow cytometry of fresh single-cell suspensions, with a panel of markers that identify the most important adaptive and innate immune cells. We found that CD45(+) leukocytes are regularly observed in the fallopian tube and are mainly composed of CD163(+) macrophages, CD11c(+) dendritic cells, and CD8(+) T cells. In addition, there are minor populations of CD56(+) NK cells, CD4(+) T cells, CD20(+) B cells, TCR gamma delta(+) T cells, and, among dendritic cells, CD207(Langerin)(+) Langerhans cells. The cellular mapping that we performed indicates that the local immune system in the human fallopian tube is composed of a mixture of innate and adaptive immune cells, many of which are recognized as playing a role in cancer immune surveillance. This local immune system could provide a first line of defense against early precancerous lesions and could potentially be exploited for immune-based therapies.
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