Journal
MICROBIAL PATHOGENESIS
Volume 89, Issue -, Pages 210-216Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2015.10.002
Keywords
IL-10; Regulatory T cells; Apoptosis; Abnormal pregnancy outcomes; Toxoplasma gondii
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Funding
- National Natural Science Foundation of China [81171591, 81273243, 81201307]
- Natural Science Foundation of Shandong Province [ZR2013HQ023, ZR2014HP010]
- Taishan Scholar Foundation
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This study aims to investigate whether IL-10 regulate decidual Treg cells apoptosis to reverse the abnormal pregnancy outcomes with Toxoplasma gondii (T. gondii) infection. Recombinant mouse IL-10 (rIL-10) treatment and IL-10 deficiency (IL-10(-/-)) abnormal pregnancy animal models with T. gondii infection were established. Apoptosis related molecules cleaved Caspase-3 and Caspase-8 in decidual Treg cells were examined using flow cytometry. The levels of cleaved Caspase-3 and Caspase-8 in decidual Treg cells were up-regulated with T gondii infection. Compared to infected group, the expressions of cleaved Caspase-3 and Caspase-8 in decidual Treg cells were down-regulated in rIL-10-treated group, while up-regulated in infected IL-10(-/-) group. In addition, pregnant outcomes were improved in rIL-10-treated group, while worse in IL-10(-/-) group compared to infected group. These findings revealed that IL-10 reduced the decidual Treg cells apoptosis contributing to improving adverse pregnant outcomes following T. gondii infection. (C) 2015 Elsevier Ltd. All rights reserved.
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