Journal
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Volume 22, Issue 7, Pages 1234-1237Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IGC.0b013e31825d4716
Keywords
Human papillomavirus 58; Integration; Repetitive element; Disruption of E1 gene
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Funding
- Beijing Municipal Science and Technology Commission [D09050703570906]
- Program for Key Infectious Diseases [2009ZX10601]
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Integration of high-risk HPV in host genome is an important event in cervical cancer development. This study was aimed to analyze the integration of HPV58, a high-risk type that is prevalent in cervical lesions from southeastern Asia. Detection of integrated papillomavirus sequences by ligation-mediated polymerase chain reaction followed by DNA sequencing revealed 8 integrations in 5 samples, and virus integration was found present in 2 samples with early lesion. Sequence analysis of the viral-cellular junctions showed that E1 disruption in virus genome was an early and common event during HPV58 infection. In 6 integrations, DNA fragments of HPV58 genome integrated into the repetitive element sequences of host genome.
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