Journal
MICROBIAL PATHOGENESIS
Volume 81, Issue -, Pages 33-38Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2015.03.010
Keywords
Helicobacter pylori; Interleukin-17; Gastritis; Peptic ulcers; Gastric cancer
Categories
Funding
- Shahrekord University of Medial Sciences [1025]
Ask authors/readers for more resources
Helicobacter pylori (H. pylori) infection is regarded as the major cause of various gastric diseases (gastritis, peptic ulcers and gastric cancer) and induces the production of several cytokines. Interleukin-17 (IL-17) is recently recognized as an important player in the pathophysiology of infectious and immune-mediated gastrointestinal diseases. Helicobacter pylori infection increases IL-17 in the gastric mucosa of humans. IL-17 usually causes secretion of IL-8 through activation of ERK 1/2 MAP kinase pathway. The released IL-8 attracts neutrophils promoting inflammation. T regulatory cells (Tregs) suppress the inflammatory reaction driven by IL-17, there by favoring bacterial persistence in Helicobacter pylori-infection. The pathogenesis of Helicobacter pylori-induced inflammation is not well understood. Inflammation is promoted by both host factors and Helicobacter pylori factors, such as the proteins cytotoxin associated gene A (cagA) and vacuolating cytotoxin A (vacA). IL-1 beta, IL-6, tumor necrosis factor (TNF)-alpha, TGF-beta 1, IL-17, IL-18, IL-21 and IL-22 have been reported to be involved in Helicobacter pylori-induced gastric mucosal inflammation, but the details and relation to different patterns of inflammation remain unclear. Numerous studies have demonstrated important functions of IL-17 in acute and chronic inflammatory processes. This paper reviews the role of IL-17 in gastritis, peptic ulcers and gastric cancer related to Helicobacter pylori. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available