Journal
MICROBES AND INFECTION
Volume 17, Issue 3, Pages 173-183Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2015.01.004
Keywords
Bacterial invasion; Bacterial adhesion; Microbiota; Host barrier; Host-pathogen interactions; Listeria
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Funding
- Institut Pasteur, INSERM, INRA, ANR [ANR-2010-PATH-001-01, ANR-2013-IFEC-0004-02, 10-BINF-02-01]
- French Government's Investissements d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases [ANR-10-LABX-62-IBEID]
- ERC [233348 MODELIST]
- Human Frontier Science Program [RGP0011/2013]
- Fondation le Roch les Mousquetaires
- Fondation Louis-Jeantet
- Howard Hughes Medical Institute
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Bacterial pathogens have evolved a wide range of strategies to colonize and invade human organs, despite the presence of multiple host defense mechanisms. In this review, we will describe how pathogenic bacteria can adhere and multiply at the surface of host cells, how some bacteria can enter and proliferate inside these cells, and finally how pathogens may cross epithelial or endothelial host barriers and get access to internal tissues, leading to severe diseases in humans. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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