Journal
MICROBES AND INFECTION
Volume 17, Issue 4, Pages 304-310Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2014.12.001
Keywords
Fungal microbiota; Paediatric inflammatory bowel disease; Gut microbiota
Categories
Funding
- Clinical Academic Training Fellowship from the Chief Scientist Office in Scotland [CAF/08/01]
- Broad Medical Research programme
- NHS Grampian Endowments
- Catherine McEwan Foundation
- Yorkhill IBD fund
- NHS research Scotland fellowship
- Medical Research Council (MRC) [G0800675]
- MRC [G0800675] Funding Source: UKRI
- Chief Scientist Office [CAF/08/01] Funding Source: researchfish
- Medical Research Council [G0800675] Funding Source: researchfish
- Medical Research Foundation [C0482] Funding Source: researchfish
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Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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