Journal
MICROBES AND INFECTION
Volume 17, Issue 2, Pages 123-134Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2014.12.006
Keywords
Influenza A virus; Subunit vaccines; Nucleoprotein; Matrix protein; Hemagglutinin
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Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R21AI111152]
- Chinese Ministry of Science & Technology, Hong Kong, Macau, Taiwan Collaborative Program [201200007673]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI111152] Funding Source: NIH RePORTER
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The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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