Journal
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
Volume 25, Issue 2, Pages 202-205Publisher
WILEY
DOI: 10.1002/gps.2321
Keywords
beta-amyloid; Alzheimer's disease; Down syndrome
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Funding
- NIH [R01-AG014763, P01-HD35897, R01-HD37425]
- National Down Syndrome Society in collaboration with the NICHD
- NYS through its Office of Mental Retardation and Developmental Disabilities
- Eisai Limited, UK
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Objectives: To investigate the relation of plasma levels of A beta peptides (A beta 1-40 and A beta 1-42) and apolipoprotein E (APOE) genotype to dementia status, and the duration of Alzheimer's disease (AD) in adults with Down syndrome (DS). Methods: Adults with DS were recruited from community settings and followed up for a mean period of 6.7 years. Plasma levels A beta 1-40 and A beta 1-42 and APOE genotype were determined at the last visit. Results: There were 83 nondemented participants and 44 participants with prevalent AD. Overall, plasma levels of A beta 1-42, A beta 1-40 and the ratio A beta 1-42/A beta 1-40 did not differ significantly between the adults with DS. Among demented participants, the mean level of A beta 1-40 was significantly lower (157.0 vs. 195.3) and the ratio of A beta 1-42/A beta 1-40 was significantly higher (0.28 vs. 0.16) in those with more than 4 years duration of dementia than in those with 4 or fewer years' duration of dementia. This pattern was generally similar in those with and without an APOE epsilon 4 allele. Conclusions: There is an association between plasma A beta peptide levels and the duration of AD in older persons with DS. The predictive and diagnostic roles of A beta 1-42 and A beta 1-40 measurements for AD, however, remain controversial. Change in A beta peptide levels with onset of AD and with the duration of dementia may account for a lack of difference between prevalent cases and nondemented individuals and for variation in the predictive power of A beta peptide levels. Copyright (C) 2009 John Wiley & Sons, Ltd.
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