Journal
MICROBES AND INFECTION
Volume 17, Issue 8, Pages 557-563Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2015.04.005
Keywords
vsRNA; siRNA; RNAi; Mammalian; RNA virus; Small RNA
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Funding
- Chang Gung Memorial Hospital [CMRPD190251similar to2, CMRPD1D0311similar to3]
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The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field. (C) 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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