Journal
MICRO & NANO LETTERS
Volume 10, Issue 2, Pages 126-129Publisher
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2014.0198
Keywords
lipid bilayers; microorganisms; cellular biophysics; drugs; scanning electron microscopy; Fourier transform infrared spectra; light scattering; electrokinetic effects; biochemistry; liposome-encapsulated ketoconazole; pharmacological therapeutic efficacy; drug delivery system; scanning electron microscopy; Fourier transformation infrared spectroscopy; dynamic light scattering; size distribution; zeta potential; zeta stability; polydispersity index; serum solution; antifungal activity; Candida sp
Funding
- National Institute of Technology, Rourkela
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Liposomal formulations containing ketoconazole were prepared with the ultimate goal of increasing their efficacy for topical drug delivery. Various concentrations of drugs were encapsulated within liposomes and characterised by scanning electron microscopy, Fourier transformation infrared spectroscopy, dynamic light scattering studies for size distribution, zeta potential and stability. LIP200 emerged as the best formulation with a size of 178.9 nm, polydispersity index of 0.299 and overall zeta potential of -5.38 mV. The encapsulation efficiency monitored over a period of 28 days varied between 79.6 and 75.4%. The formulation was found to be stable in serum solution with slight changes in size, polydispersity index and charge. The formulation also showed a better anti-fungal activity against Candida sp. in comparison to other preparations, as well as the control, indicating its potential as a promising topical drug delivery system.
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