Journal
METHODS
Volume 89, Issue -, Pages 54-63Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2015.06.010
Keywords
Proteomics; Mass spectrometry; Structure; Quantitation; Systems biology; Cross-linking; XL-MS
Funding
- Medical Research Council - United Kingdom
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With the continuing trend to study larger and more complex systems, the application of protein cross-linking coupled with mass spectrometry (XL-MS) provides a varied toolkit perfectly suited to achieve these goals. By freezing the transient interactions through the formation of covalent bonds, XL-MS provides a vital insight into both the structure and organization of proteins in a wide variety of conditions. This review covers some of the established methods that underpin the field alongside the more recent developments that hold promise to further realize its potential in new directions. (C) 2015 The Author. Published by Elsevier Inc. This is an open access article under the CC BY license.
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