Journal
METHODS
Volume 72, Issue -, Pages 51-56Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2014.10.010
Keywords
Epigenome; High-throughput sequencing; Single cell; Methylation; Chromatin
Funding
- Rita Allen Foundation Young Scholar
- NIH [P50HG007735, U19AI057266]
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Spectacular advances in the throughput of DNA sequencing have allowed genome-wide analysis of epigenetic features such as methylation, nucleosome position and post-translational modification, chromatin accessibility and connectivity, and transcription factor binding. However, for rare or precious biological samples, input requirements of many of these methods limit their application. In this review we discuss recent advances for low-input genome-wide analysis of chromatin immunoprecipitation, methylation, DNA accessibility, and chromatin conformation. (C) 2014 Elsevier Inc. All rights reserved.
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