Journal
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
Volume 91, Issue 5, Pages 387-393Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2613.2010.00749.x
Keywords
apoptosis; cartilage; chemotherapy; chondrocytes; chondrosarcoma; radiation
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Funding
- Medical Research Council
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P>Chondrosarcomas are malignant cartilage tumours. They are poorly responsive to chemotherapy and radiotherapy. Treatment is usually limited to surgical resection; however, survival of patients with high-grade chondrosarcoma is poor, even with wide surgical resection. Induction of apoptosis in chondrosarcoma cells, either directly or by enhancement of the response to chemotherapeutic drugs and radiation, may be a route by which outcome can be improved. In this article, we review potential molecular targets that regulate chondrocyte apoptosis and discuss the experimental evidence for their utility.
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