Journal
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Volume 41, Issue 6, Pages 1776-1785Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ije/dys149
Keywords
Coronary heart disease; mortality; intergenerational; height
Categories
Funding
- Scottish Home and Health Department
- Renfrewshire King Edward Memorial Trust
- Wellcome Trust
- National Health Service Cardiovascular Research & Development Programme
- Wellcome Trust [081021]
- UK Medical Research Council [U.1300.00.006.00012.01]
- Chief Scientist Office at the Scottish Government Health Directorates
- MRC [MC_UP_A540_1021, MC_U130059821] Funding Source: UKRI
- Medical Research Council [MC_U130059821, G9815508, MC_UP_A540_1021] Funding Source: researchfish
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Background Adult height is known to be inversely related to coronary heart disease (CHD) risk. We sought to investigate the transgenerational influence of parental height on offspring's CHD risk. Methods Parents took part in a cardiorespiratory disease survey in two Scottish towns during the 1970s, in which their physical stature was measured. In 1996, their offspring were invited to participate in a similar survey, which included an electrocardiogram recording and risk factor assessment. Results A total of 2306 natural offspring aged 30-59 years from 1456 couples were subsequently flagged for notification of mortality and followed for CHD-related hospitalizations. Taller paternal and/or maternal height was associated with socio-economic advantage, heavier birthweight and increased high-density lipoprotein cholesterol in offspring. Increased height in fathers, but more strongly in mothers (risk ratio for 1 SD change in maternal height = 0.85; 95% confidence interval: 0.76 to 0.95), was associated with a lower risk of offspring CHD, adjusting for age, sex, other parental height and CHD risk factors. Conclusion There is evidence of an association between taller parental, particularly maternal, height and lower offspring CHD risk. This may reflect an influence of early maternal growth on the intrauterine environment provided for her offspring.
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