Journal
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Volume 39, Issue 2, Pages 417-420Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyp334
Keywords
Bias; selection; methods; epidemiologic
Categories
Funding
- NCI NIH HHS [CA16086] Funding Source: Medline
- NIAAA NIH HHS [R01-AA-01759] Funding Source: Medline
- NIAID NIH HHS [P30-AI-50410, R03 AI071763, T32 AI007001, R03-AI-071763] Funding Source: Medline
- NIEHS NIH HHS [P30-ES-10126] Funding Source: Medline
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That conditioning on a common effect of exposure and outcome may cause selection, or collider-stratification, bias is not intuitive. We provide two hypothetical examples to convey concepts underlying bias due to conditioning on a collider. In the first example, fever is a common effect of influenza and consumption of a tainted egg-salad sandwich. In the second example, case-status is a common effect of a genotype and an environmental factor. In both examples, conditioning on the common effect imparts an association between two otherwise independent variables; we call this selection bias.
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