Journal
METALLOMICS
Volume 7, Issue 6, Pages 943-956Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5mt00012b
Keywords
-
Categories
Funding
- National Institutes of Health [R21AI099747]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI099747] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Iron-sulfur clusters act as important cofactors for a number of transcriptional regulators in bacteria, including many mammalian pathogens. The sensitivity of iron-sulfur clusters to iron availability, oxygen tension, and reactive oxygen and nitrogen species enables bacteria to use such regulators to adapt their gene expression profiles rapidly in response to changing environmental conditions. In this review, we discuss how the [4Fe-4S] or [2Fe-2S] cluster-containing regulators FNR, Wbl, aconitase, IscR, NsrR, SoxR, and AirSR contribute to bacterial pathogenesis through control of both metabolism and classical virulence factors. In addition, we briefly review mammalian iron homeostasis as well as oxidative/nitrosative stress to provide context for understanding the function of bacterial iron-sulfur cluster sensors in different niches within the host.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available