Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Volume 31, Issue 6, Pages 424-433Publisher
WILEY
DOI: 10.1016/j.ijdevneu.2013.02.006
Keywords
Neural stem cells; Transcription factor; Epigenetics; Corticogenesis; Projection neurons; Cortical layer
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labour and Welfare, Japan
- Japan Society for the Promotion. of Science
- Grants-in-Aid for Scientific Research [11J09295, 12J08939] Funding Source: KAKEN
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The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs. (C) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
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