Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Volume 29, Issue 7, Pages 701-710Publisher
WILEY
DOI: 10.1016/j.ijdevneu.2011.06.002
Keywords
Ayurveda; Akt; Pediatric cancer; Nutrition; Chemotherapy
Categories
Funding
- National Institutes of Health [NS065172]
- American Heart Association [BGIA2300135, 2250690]
- A.R. Staulcup Foundation
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Neuroblastoma (NB) is the most prevalent pediatric solid tumor and a leading cause of cancer-related death in children. In the present study, a novel cytotoxic role for the dietary compounds, curcumin, andrographolide, wedelolactone, dibenzoylmethane, and tanshinone IIA was identified in human S-type NB cells, SK-N-AS and SK-N-BE(2). Mechanistically, cell death appeared apoptotic by flow cytometry; however, these effects proceeded independently from both caspase-3 and p53 activation, as assessed by both genetic (shRNA) and pharmacological approaches. Notably, cell death induced by both curcumin and andrographolide was associated with decreased NF kappa B activity and a reduction in Bcl-2 and Bcl-xL expression. Finally, curcumin and andrographolide increased cytotoxicity following co-treatment with either cisplatin or doxorubicin, two chemotherapeutic agents widely used in the clinical management of NB. Coupled with the documented safety in humans, dietary compounds may represent a potential adjunct therapy for NB. (C) 2011 ISDN. Published by Elsevier Ltd. All rights reserved.
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