Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Volume 29, Issue 1, Pages 31-36Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijdevneu.2010.10.001
Keywords
MicroRNA; Sox9; Spinal cord development; Neuroepithelial cells; Developmental neurobiology
Categories
Funding
- Science Foundation Ireland (SFI)
- Programme for Research in Third Level Institutions (PRTLI)
- Health Research Board
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Central nervous system development is a complex process involving many interacting factors. MicroRNAs have recently been identified as playing key intrinsic roles in development however few of their specific targets have been identified in vivo. The transcription factor Sox9 has recently been identified as a target of miR-124 in the adult mouse sub-ventricular zone. Here we investigate the expression of the microRNAs miR-124, miR-128 and miR-23 and that of transcription factor Sox9, in neuroepithelial stem cells in the developing spinal cord. Furthermore we investigate if neurogenesis in embryonic neuroepithelial cells in the spinal cord might also be regulated by the interaction of Sox9 and miR-124. We provide evidence of the spatial and temporal regulation of miR-124, miR-128, miR-23 and Sox9, and taken together with recent findings we provide evidence that Sox9 may also be target of miR-124 in developing spinal cord neuroepithelial cells. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
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