Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 56, Issue 1-3, Pages 53-65Publisher
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.113451ma
Keywords
planarian; Wnt signalling; regeneration; development; axial polarity
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Funding
- Ministerio de Educacion y Ciencia (MEC), Spain [BFU2008-01544]
- University of Barcelona
- MEC
- [2009SGR1018]
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Wnts are secreted glycoproteins involved in a broad range of essential cell functions, including proliferation, migration and cell-fate determination. Recent years have seen substantial research effort invested in elucidating the role of theWnt signaling pathway in planarians, flatworms with incredible regenerative capacities. In this review, we summarize current knowledge on the role of canonical (beta-catenin-dependent) and non-canonical (beta-catenin-independent) Wnt signaling in planarians, not only during regeneration, but also during normal homeostasis. We also describe some of the preliminary data that has been obtained regarding the role of these pathways during embryogenesis. Models are proposed to integrate the different results which have been obtained to date and highlight those questions that still remain to be answered.
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