Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 56, Issue 6-8, Pages 479-487Publisher
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.113461dm
Keywords
germline; stem cell; heat shock; FoxO; insulin
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Funding
- National Institute On Aging [1R01AG037965-01]
- NATIONAL INSTITUTE ON AGING [R01AG037965] Funding Source: NIH RePORTER
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Existing data imply that the cnidarian Hydra vulgaris does not undergo senescence. In contrast, the related species Hydra oligactis shows increased mortality and physiological deterioration following sexual reproduction. Hydra thus offers the chance to study a striking difference in lifespan in members of the same genus. Adult Hydra possess three well-characterized stem cell populations, one of which gives rise to both somatic cells and gametes. The lack of senescence in Hydra vulgaris raises the question of how these stem cell populations are maintained over long periods of time. Investigation of the roles in Hydra of proteins involved in cellular stress responses in other organisms should provide insight into this issue. Proteins of particular interest include the Hsp70 family proteins and the transcription factor FoxO.
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