Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 55, Issue 7-9, Pages 763-771Publisher
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.113385mm
Keywords
differentiation; extracellular matrix; intercellular signaling; stem cells; tumorigenesis
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Funding
- La Ligue Nationale Contre le Cancer (Equipe Labelisee)
- Agence Nationale de la Recherche [ANR-08-BLAN-0078-01]
- Association pour la Recherche sur le Cancer
- Institut Curie and Servier Laboratories
- Canceropole Ile de France
- Agence Nationale de la Recherche
- La Fondation pour la Recherche Medicale
- Institut National du Cancer
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Over the last few years, the discovery of basal-type mammary carcinomas and the association of the regenerative potential of the mammary epithelium with the basal myoepithelial cell population have attracted considerable attention to this second major mammary lineage. However, many questions concerning the role of basal myoepithelial cells in mammary morphogenesis, functional differentiation and disease remain unanswered. Here, we discuss the mechanisms that control the myoepithelial cell differentiation essential for their contractile function, summarize new data concerning the roles played by cell-extracellular matrix (ECM), intercellular and paracrine interactions in the regulation of various aspects of the mammary basal myoepithelial cell functional activity. Finally, we analyze the contribution of the basal myoepithelial cells to the regenerative potential of the mammary epithelium and tumorigenesis.
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