Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 52, Issue 5-6, Pages 677-682Publisher
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.072528ek
Keywords
egg; zona pellucida; acrosome reaction; penetration; hyaluronidase; proteolysis
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Funding
- Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT)
- Japan Society for the Promotion of Science (JSPS)
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Mammalian fertilization requires sperm to penetrate the cumulus mass and egg zona pellucida prior to fusion with the egg. Although sperm penetration through these physical barriers is essential, the molecular mechanism has not yet been completely elucidated. In addition to sperm motility, hyaluronan-hydrolyzing and proteolytic enzymes of sperm have been suggested to participate in the penetration events. Here we focus on the functional roles of hyaluronidase and protease in sperm passage through the cumulus mass and zona pellucida.
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