Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 52, Issue 5-6, Pages 607-613Publisher
U B C PRESS
DOI: 10.1387/ijdb.072554bn
Keywords
CatSper; KSper; Ca2+; hyperactivated sperm motility; patch clamp; sperm; Ca2+ channel
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [T32 HL007572] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007572] Funding Source: NIH RePORTER
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Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSIo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.
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