Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 52, Issue 8, Pages 1051-1057Publisher
U B C PRESS
DOI: 10.1387/ijdb.082657gs
Keywords
Ceratitis; sex determination; DSXM isoform
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Funding
- Ministero della Ricerca Scientifica e Tecnologica
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The Doublesex (DSX) transcription factor regulates somatic sexual differentiation in Drosophila melanogaster. Female and male isoforms (DSXF and DSXM) are produced due to sex-specific RNA splicing. Here we show that in the distantly related dipteran Ceratitis capitata, the DSXM male-specific isoform is conserved and able to induce masculinization of both somatic and germline tissues when ectopically expressed in XX Drosophila transgenic individuals.
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