Journal
INTERNATIONAL JOURNAL OF DERMATOLOGY
Volume 54, Issue 6, Pages 672-674Publisher
WILEY
DOI: 10.1111/ijd.12392
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IntroductionVitiligo is a common progressive depigmentation of the skin due to selective destruction of melanocytes. Nowadays increasing evidences support the hypothesis of an autoimmune etiology. MethodsIn order to sustain the role of T-helper-17 lymphocytes in the pathogenesis of vitiligo, wemeasured the serum levels of interleukin (IL)-23 (an important regulator of this subset) using a quantitative enzyme immunoassay technique in 12 males and 16 females (ages ranging from 18 to 58years) affected by non-segmental vitiligo and compared the results with a group of healthy donors. ResultsIL-23 serum levels were significantly higher in patients withvitiligo as compared with controls. There was a significant positive correlation of IL-23 serum levels with disease duration and extent of vitiligo and disease activity. ConclusionsThe inhibition of IL-23 might be a novel strategy in the therapy of autoimmune inflammatory diseases likevitiligo.
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