Journal
INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS
Volume 5, Issue 5, Pages 519-531Publisher
INDERSCIENCE ENTERPRISES LTD
DOI: 10.1504/IJDMB.2011.043031
Keywords
miRNA; microRNA; biomarker; TFs; transcription factors; TSS; transcription start site; miRNA target; angiogenesis; gastric cancer; chronic gastritis; TFBS; transcription factor binding site
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Funding
- NSFC [60934004, 60805009]
- China Postdoctoral Science Foundation
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MicroRNAs (miRNAs) are potential biomarkers in the diagnosis of human disease. In this study, a novel concept, the miRNA network biomarker, was proposed for the selection of biomarkers. Each miRNA network biomarker contains miRNA targets, as well as Transcription Factors (TFs), that affect the miRNA expression. The obtained biomarkers were applied to classifying expression data sets in different progression stages from chronic gastritis to gastric cancer. Furthermore, these biomarkers could accurately (94%) discriminate gastric cancer samples from normal samples in another data set. Angiogenesis-related pathways and genes were found to be enriched in these network biomarkers.
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