Journal
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Volume 68, Issue 12, Pages 1462-1466Publisher
WILEY-BLACKWELL
DOI: 10.1111/ijcp.12534
Keywords
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Funding
- Shanghai Natural Science Foundation [12ZR1429000]
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ObjectiveThis study was designed to examine the relevance of single-nucleotide polymorphism (SNP) rs11212617 with treatment success in type 2 diabetes patients from Shanghai local Chinese Han population. MethodsWe genotyped rs11212617 in incident metformin users of type 2 diabetes patients from Shanghai local Chinese Han population. Association between rs11212617 and changes in HbA1c, fasting plasma glucose and postprandial glucose level were analysed. ResultsTwo hundred and seventy-four incident metformin users were included in the study sample. The SNP rs11212617 was significantly associated with metformin response in Shanghai local Chinese Han population. ConclusionThe rs11212617 is associated with a reduction in HbA1c, fasting plasma glucose and postprandial glucose level. These results suggest that metformin treatment may be more efficacious in Shanghai and valuable for Chinese daily clinical practice.
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