Journal
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Volume 65, Issue 4, Pages 458-464Publisher
WILEY
DOI: 10.1111/j.1742-1241.2010.02597.x
Keywords
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Funding
- Slovenian Research Agency (ARRS) [L3-0328]
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P>Background: The current guidelines emphasise the need to assess kidney function using predictive equations rather than just serum creatinine. The present study compares serum cystatin C-based equations and serum creatinine-based equations in patients with chronic kidney disease (CKD). Methods: Seven hundred and sixty-four adult patients with CKD were enrolled. In each patient serum creatinine and serum cystatin C were determined. Their glomerular filtration rate (GFR) was estimated using three serum creatinine-based equations [Cockcroft-Gault (C&G), modification of diet in renal disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI)] and two serum cystatin C-based equations [our own cystatin C formula (GFR = 90.63 x cystatin C-1.192) and simple cystatin C formula (GFR = 100/cystatin C)]. The GFR was measured using 51CrEDTA clearance. Results: Statistically significant correlation between 51CrEDTA clearance with serum creatinine, serum cystatin C and all observed formulas was found. The receiver operating characteristic curve analysis (cut-off for GFR 60 ml/min/1.73 m2) showed that serum cystatin C and both cystatin C formulas had a higher diagnostic accuracy than C&G formula. Bland and Altman analysis for the same cut-off value showed that all formulas except simple cystatin C formula underestimated measured GFR. The accuracy within 30% of estimated 51CrEDTA clearance values differs according to stages of CKD. Analysis of ability to correctly predict patient's GFR below or above 60 ml/min/1.73 m2 showed statistically significant higher ability for both cystatin C formulas compared to MDRD formula. Conclusion: Our results indicate that serum cystatin C-based equations are reliable markers of GFR comparable with creatinine-based formulas.
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