Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 167, Issue 4, Pages 1101-1108Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2012.09.089
Keywords
Cirrhosis; Portal hypertension; Hyperdynamic circulation; Systolic dysfunction; Diastolic dysfunction; Prolonged QT interval
Categories
Funding
- NovoNordisk Foundation
- Novo Nordisk Fonden [NNF13OC0006329, NNF11OC1015075, NNF11OC1014467] Funding Source: researchfish
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Cirrhotic cardiomyopathy designates a cardiac dysfunction, which includes reduced cardiac contractility with systolic and diastolic dysfunction, and presence of electrophysiological abnormalities in particular prolongation of the QT interval. Several pathophysiological mechanisms including reduced beta-receptor function seem involved in the autonomic and cardiac dysfunction. Cirrhotic cardiomyopathy can be revealed by tissue Doppler imaging but is best demasked by physical or pharmacological stress. Liver transplantation may revert cardiac dysfunction but surgery and shunt insertion may also aggravate the condition. Moreover, cirrhotic cardiomyopathy may contribute to heart failure after invasive procedures and to development of hepatic nephropathy as part of a cardiorenal syndrome. Whether beta-blockers have a deleterious effect in this clinical situation remains to be settled. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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