Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 167, Issue 1, Pages 22-25Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2012.05.082
Keywords
Cardiac regeneration; Adipose flap; Myocardial infarction
Categories
Funding
- Ministerio de Ciencia e Innovacion [SAF 2008-05144-C02-01, SAF 2011-30067-C02-01]
- La Marato de TV3 [080330]
- Fundacio Privada Daniel Bravo Andreu
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The human heart has limited regenerative capacity. We focused on cardiac adipose tissue as a source of progenitor cells and biological matrix material for salvaging injured myocardium. First, a population of human adult mesenchymal-like progenitors derived from cardiac adipose tissue, with inherent cardiac and endothelial cell potential, was identified and characterized. Next, a salvage strategy was tested, where a pericardial-derived, vascularized, adipose flap was used to cover oxygen-deprived myocardium in a porcine model. The fat flap reduced the myocardial scar size, in both acute and chronic infarcts. A human clinical trial to examine this novel intervention is currently underway. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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