Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 145, Issue 2, Pages 172-176Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2010.04.082
Keywords
Coronary artery disease; Chronic obstructive pulmonary disease; Systemic inflammation; C-reactive protein; Chronic systemic inflammatory syndrome
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Funding
- Deutsche Forschungsgemeinschaft [KFO 196]
- Ministry of Science and Education of the State of the Saarland, Germany
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Coronary artery disease (CAD), chronic heart failure (CHF) or chronic obstructive pulmonary disease (COPD) occur commonly in the presence of each other and are associated with similar systemic inflammatory reactions. Inflammation plays a central role in the pathogenesis of these diseases. C-reactive protein (CRP) could represent the sentinel biomarker to all chronic diseases. Also, interleukin (IL)-6 may play a causal role in systemic inflammatory diseases. These complex interactions between heart and lung can be denoted as 'cardiopulmonary continuum'. Common risk factors induce systemic inflammatory processes which lead to progression of atherosclerotic diseases as well as COPD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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