Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 130, Issue 2, Pages 147-158Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2008.04.059
Keywords
Macrophage; Myocardial infarction; Matrix metalloproteinases; Left ventricular remodeling; Angiogenesis; Fibrosis
Categories
Funding
- National Institutes of Health (National Heart Lung and Blood Institute) [HL-75360, HL-75360S1]
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Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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