Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 144, Issue 12, Pages 2909-2917Publisher
WILEY
DOI: 10.1002/ijc.31850
Keywords
B lymphocytes; regulatory B cells; tumor immunity; prognosis; immunotherapy
Categories
Funding
- National Key Technology RD Program [2015BAI12B12]
- National Natural Science Foundation of China [81472471]
Ask authors/readers for more resources
Our previous understanding of the role of B lymphocytes in tumor immunity is its antitumor effects. However, further evidence indicates B lymphocytes can also promote tumorigenesis by modulating immune responses. Therefore, the increasingly complex role of B lymphocytes in tumor immunity may become an important factor in tumor immunotherapy. In this review, we describe the development of B cells in tumor microenvironments. We then focus on the most controversial issues of the biological functions of B lymphocytes. Finally, we nominate B cells as therapeutic targets, which should open broad perspectives for the development of their clinical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available