Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 137, Issue 3, Pages 504-511Publisher
WILEY
DOI: 10.1002/ijc.28972
Keywords
connective tissue growth factor (CTGF); cancer; CCN2
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Funding
- Children's Leukaemia and Cancer Research Foundation, Perth, WA, Australia
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Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers. The role it plays in these neoplasms is diverse and tumour specific. Recurring patterns in clinical outcome, histological desmoplasia and mechanisms of action have been found. When CTGF is overexpressed compared to low-expressing normal tissue or is underexpressed compared to high-expressing normal tissue, the functional outcome favours tumour survival and disease progression. CTGF acts by altering proliferation, drug resistance, angiogenesis, adhesion and migration contributing to metastasis. The pattern of CTGF expression and tumour response helps to clarify the role of this matricellular protein across a multitude of human cancers.
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