Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 136, Issue 6, Pages 1245-1253Publisher
WILEY
DOI: 10.1002/ijc.28755
Keywords
Six1; cancer; organs development; disease
Categories
Funding
- Natural Science Foundation of Jiangsu Province [BK20130693]
- Youth Science and Technology Innovation Fund of Nanjing Agricultural College [KJ2012014]
- National Natural Science Foundation of China [31172187, 31000996]
- 973 Program [2014CB138502]
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In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a powerful regulator of organogenesis and disease, with important roles in tumorigenesis; therefore, it is important to review the biology of Six1 gene comprehensively. This review describes the function of Six1 in normal organ development, summarizes its role in several diseases, including cancer. The review will extend our understanding about the functional roles of Six1 and suggests opportunities to target Six1 for diagnostic, prognostic, and therapeutic purposes.
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