Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 134, Issue 9, Pages 2223-2230Publisher
WILEY
DOI: 10.1002/ijc.28545
Keywords
mass screening; papanicolaou smear; cervical intraepithelial neoplasia; HPV; non-attendance
Categories
Funding
- Swedish Cancer Society
- Health & Medical Care Committee of the Regional Executive Board
- Vastra Gotaland Region
- Swedish Association of Local Authorities and Regions (SKL)
- Skaraborg Research and Development Council
- Gothenburg Medical Society
- Assar Gabrielsson's Fund
Ask authors/readers for more resources
RACOMIP is a population-based, randomized trial of the effectiveness and cost-effectiveness of different interventions aimed at increasing participation in a well-run cervical cancer screening program in western Sweden. In this article, we report results from one intervention, offering non-attendees a high-risk human papillomavirus (HPV) self-test. Comparison was made with standard screening invitation routine or standard routine plus a telephone call. Women (8,800), aged 30-62, were randomly selected among women without a registered Pap smear in the two latest screening rounds. These women were randomized 1:5:5 to one of three arms: 800 were offered a high-risk HPV self-test, 4,000 were randomized to a telephone call (reported previously) and 4,000 constituted a control group (standard screening invitation routine). Results were based on intention to treat analysis and cost-effectiveness was calculated as marginal cost per cancer case prevented. The endpoint was the frequency of testing. The total response rate in the self-testing arm was 24.5 %, significantly higher than in the telephone arm (18 %, RR 1.36, 95 % CI 1.19-1.57) and the control group (10.6 %, RR 2.33, 95 % CI 2.00-2.71). All nine women who tested positive for high-risk HPV attended for a cervical smear and colposcopy. From the health-care sector perspective, the intervention will most likely lead to no additional cost. Offering a self-test for HPV as an alternative to Pap smears increases participation among long-term non-attendees. Offering various screening options can be a successful method for increasing participation in this group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available