Related references
Note: Only part of the references are listed.Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy
M. Maugeri-Sacca et al.
CANCER TREATMENT REVIEWS (2013)
CRL4(CDT2) Targets CHK1 for PCNA-Independent Destruction
Jiwon Huh et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer
J. Xu et al.
ONCOGENE (2013)
Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress
Yukihiro Furusawa et al.
APOPTOSIS (2012)
Interferon-gamma enhances radiation-induced cell death via downregulation of Chk1
Kwang Seok Kim et al.
CANCER BIOLOGY & THERAPY (2012)
Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1
Jingna Wang et al.
CANCER RESEARCH (2012)
Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy
M. Bartucci et al.
CELL DEATH AND DIFFERENTIATION (2012)
A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair
Ko Sato et al.
CURRENT BIOLOGY (2012)
Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response
Chen Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability
Jingna Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
Jian Hong et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
Cynthia X. Ma et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
Andres J. Lopez-Contreras et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation
Ping Li et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis
L. M. Tho et al.
ONCOGENE (2012)
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
R. Hromas et al.
ONCOGENE (2012)
Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma
Oluf Dimitri Roe et al.
PLOS ONE (2012)
Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints
Navjotsingh Pabla et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer
Christina N. Bennett et al.
BREAST CANCER RESEARCH (2012)
Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks
Ae Jeong Kim et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation
Jean-Hugues Guervilly et al.
HUMAN MOLECULAR GENETICS (2011)
Phosphorylation at serine 331 is required for Aurora B activation
Eleni Petsalaki et al.
JOURNAL OF CELL BIOLOGY (2011)
Nuclear Chk1 prevents premature mitotic entry
Makoto Matsuyama et al.
JOURNAL OF CELL SCIENCE (2011)
Checkpoint Kinase 1 Prevents Cell Cycle Exit Linked to Terminal Cell Differentiation
Zakir Ullah et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1
Zheng Meng et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage
Adam M. Schmitt et al.
MOLECULAR CELL (2011)
The Expression of DNA Damage Checkpoint Proteins and Prognostic Implication in Metastatic Brain Tumors
Ho Jun Seol et al.
ONCOLOGY RESEARCH (2011)
Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation
Josep V. Forment et al.
PLOS ONE (2011)
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase
Masaoki Kawasumi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors
Ju-Hee Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
Kristina A. Cole et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
Cynthia X. Ma et al.
TRENDS IN MOLECULAR MEDICINE (2011)
A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
Melanie Blasius et al.
GENOME BIOLOGY (2011)
Targeting the checkpoint kinase Chk1 in cancer therapy
Callie Merry et al.
CELL CYCLE (2010)
New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network
Yun Dai et al.
CLINICAL CANCER RESEARCH (2010)
FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling
Sarah Luke-Glaser et al.
EMBO JOURNAL (2010)
14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
Kousuke Kasahara et al.
EMBO JOURNAL (2010)
Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families
Szilvia Solyom et al.
FAMILIAL CANCER (2010)
RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells
Shilpi Arora et al.
GYNECOLOGIC ONCOLOGY (2010)
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
Yiyong Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Requirement of MTA1 in ATR-mediated DNA Damage Checkpoint Function
Da-Qiang Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2
Naihan Xu et al.
JOURNAL OF CELL BIOLOGY (2010)
Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response
Elke Malzer et al.
JOURNAL OF CELL SCIENCE (2010)
Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage
Sarabpreet Kaur et al.
MOLECULAR CANCER RESEARCH (2010)
Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53
T. Fishler et al.
ONCOGENE (2010)
Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis
Nathan C. Boles et al.
PLOS ONE (2010)
Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells
William Brazelle et al.
PLOS ONE (2010)
Chk1 promotes replication fork progression by controlling replication initiation
Eva Petermann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy
Cindy Cavelier et al.
CANCER RESEARCH (2009)
DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress
Van Leung-Pineda et al.
CANCER RESEARCH (2009)
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction
Gang Zhi et al.
CANCER RESEARCH (2009)
Replication stress activates DNA polymerase alpha-associated Chk1
Lorena Taricani et al.
CELL CYCLE (2009)
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
Travis H. Stracker et al.
DNA REPAIR (2009)
Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G2/M Transition
Masato Enomoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Interaction with Checkpoint Kinase 1 Modulates the Recruitment of Nucleophosmin to Chromatin
Songbi Chen et al.
JOURNAL OF PROTEOME RESEARCH (2009)
Checkpoint Signaling from a Single DNA Interstrand Crosslink
Merav Ben-Yehoyada et al.
MOLECULAR CELL (2009)
The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress
You-Wei Zhang et al.
MOLECULAR CELL (2009)
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
Marina Melixetian et al.
NATURE CELL BIOLOGY (2009)
Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress
T-P Sun et al.
ONCOGENE (2009)
Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
M. Walker et al.
ONCOGENE (2009)
Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
K. R. Greenow et al.
ONCOGENE (2009)
The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis
Sirisha Peddibhotla et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cyclin A-Cdk1 regulates the origin firing program in mammalian cells
Yuko Katsuno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
Midori Shimada et al.
CELL (2008)
Cleavage-mediated activation of Chk1 during apoptosis
Kenkyo Matsuura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function
Jennifer Scorah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of Chk1 by Its C-terminal Domain
Ana Kosoy et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
ATR: an essential regulator of genome integrity
Karlene A. Cimprich et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Importance of a C-Terminal Conserved Region of Chk1 for Checkpoint Function
Carmela Palermo et al.
PLOS ONE (2008)
Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control
Deborah Wilsker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
DNA methylation inhibitor 5-aza-2 '-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
Stela S. Palii et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
Katja Lundgren et al.
BREAST CANCER RESEARCH (2008)
A proteomics analysis of cell signaling alterations in colorectal cancer
Juan Madoz-Gurpide et al.
MOLECULAR & CELLULAR PROTEOMICS (2007)
The mammalian DNA replication elongation checkpoint - Implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses
Chiara Conti et al.
CELL CYCLE (2007)
Phosphorylation of the tumor suppressor p33ING1b at Ser-126 influences its protein stability and proliferation of melanoma cells
Marco Garate et al.
FASEB JOURNAL (2007)
The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor-/progesterone receptor-/HER-2-: Breast carcinomas
Lieve Verlinden et al.
CANCER RESEARCH (2007)
Fission yeast Rnf4 homologs are required for DNA repair
Ana Kosoy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Chk1 frameshift mutation in sporadic and hereditary non-polyposis colorectal cancers with microsatellite instability
C. J. Kim et al.
EJSO (2007)
The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members
Ashley L. Craig et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif
Myoung-Ae Kim et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2007)
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
Spencer J. Collis et al.
NATURE CELL BIOLOGY (2007)
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint
Daniel Stauffer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cross-talk between Chk1 and Chk2 in double-mutant thymocytes
Kathrin Zaugg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Chk1 is required for spindle checkpoint function
George Zachos et al.
DEVELOPMENTAL CELL (2007)
Checkpoint kinase 1 is cleaved in a caspase-dependent pathway during genotoxic stress-induced apoptosis
Naoyuki Okita et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)
Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway
XiaoZhe Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
Hiroyuki Niida et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao et al.
NATURE (2006)
Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo
Erik S. Zimmerman et al.
JOURNAL OF VIROLOGY (2006)
CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage
Estelle Schmitt et al.
JOURNAL OF CELL SCIENCE (2006)
The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism
Peijun Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)
Jiabin Tang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Destruction of claspin by SCFβTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
Niels Mailand et al.
MOLECULAR CELL (2006)
SCFβTrCP-mediated degradation of claspin regulates recovery from the DNA replication checkpoint response
Angelo Peschiaroli et al.
MOLECULAR CELL (2006)
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
Shizhou Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling
Gemma K. Alderton et al.
NATURE CELL BIOLOGY (2006)
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1)
T Shiromizu et al.
GENES TO CELLS (2006)
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
S Bekker-Jensen et al.
JOURNAL OF CELL BIOLOGY (2006)
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
JS Myers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures
HY Yoo et al.
GENES & DEVELOPMENT (2006)
Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase
E Petermann et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
14-3-3γ binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
YT Jin et al.
EMBO JOURNAL (2006)
ATM regulates ATR chromatin loading in response to DNA double-strand breaks
M Cuadrado et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
VAJ Smits et al.
CURRENT BIOLOGY (2006)
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri et al.
NATURE CELL BIOLOGY (2006)
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
SY Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Genotoxic stress targets human Chk1 for degradation by the ubipuitin-proteasome pathway
YW Zhang et al.
MOLECULAR CELL (2005)
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
CAL Clarke et al.
BIOCHEMICAL JOURNAL (2005)
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
XB Lu et al.
GENES & DEVELOPMENT (2005)
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
RG Syljuåsen et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Coupling of human circadian and cell cycles by the timeless protein
K Ünsal-Kaçmaz et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
P53C-terminal phosphorylation by CHM and CHK2 participates in the regulation of DNA-Damage-induced C-terminal acetylation
YH Ou et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
S Rocha et al.
EMBO JOURNAL (2005)
The Drosophila Grp/Chk1 DNA damage checkpoint controls entry into anaphase
A Royou et al.
CURRENT BIOLOGY (2005)
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
CS Sorensen et al.
NATURE CELL BIOLOGY (2005)
Chk1 is essential for tumor cell viability following activation of the replication checkpoint
SH Cho et al.
CELL CYCLE (2005)
Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function
S Dunaway et al.
JOURNAL OF CELL SCIENCE (2005)
Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
Y Katsuragi et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis
V Galvan et al.
FEBS LETTERS (2004)
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
S Sengupta et al.
JOURNAL OF CELL BIOLOGY (2004)
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
A Krämer et al.
NATURE CELL BIOLOGY (2004)
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
K Uto et al.
EMBO JOURNAL (2004)
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
XZ Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays
V Sriuranpong et al.
CLINICAL CANCER RESEARCH (2004)
Phosphorylation of the regulatory β-subunit of protein kinase CK2 by checkpoint kinase Chk1:: identification of the in vitro CK2β phosphorylation site
LP Kristensen et al.
FEBS LETTERS (2004)
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
MH Lam et al.
CANCER CELL (2004)
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites
KC Das et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)
Structure and regulation of Src family kinases
TJ Boggon et al.
ONCOGENE (2004)
Checking on DNA damage in S phase
J Bartek et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress
SJH Arlander et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding
MS Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R
M Roshal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells
P Perego et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345
KC Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
A Groth et al.
EMBO JOURNAL (2003)
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
CS Sorensen et al.
CANCER CELL (2003)
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
G Zachos et al.
EMBO JOURNAL (2003)
被撤回的出版物: p73 alpha regulation by Chk1 in response to DNA damage (Retracted article. See vol. 37, 2017)
S Gonzalez et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Characterization of the 5 ' Flanking Region of the Human Chk1 Gene Identification of E2F1 Functional Sites
Laura Carrassa et al.
CELL CYCLE (2003)
ATR regulates fragile site stability
AM Casper et al.
CELL (2002)
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
TP Heffernan et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest
H Capasso et al.
JOURNAL OF CELL SCIENCE (2002)
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
H Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
RS Cha et al.
SCIENCE (2002)
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition
K Shimuta et al.
EMBO JOURNAL (2002)
A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle
E Shtivelman et al.
CURRENT BIOLOGY (2002)
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach
T O'Neill et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The Ded1 DEAD box helicase interacts with Chk1 and Cdc2
HY Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
RI Yarden et al.
NATURE GENETICS (2002)
Hypoxia links ATR and p53 through replication arrest
EM Hammond et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Cloning and characterization of liver-specific isoform of Chk1 gene from rat
YJ Shann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
K Koniaras et al.
ONCOGENE (2001)
Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast
A Lopez-Girona et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
C Feijoo et al.
JOURNAL OF CELL BIOLOGY (2001)
The DNA replication checkpoint response stabilizes stalled replication forks
M Lopes et al.
NATURE (2001)
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
JA Tercero et al.
NATURE (2001)
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
H Zhao et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function
H Wang et al.
GENES & DEVELOPMENT (2001)
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
J Falck et al.
NATURE (2001)
Positive regulation of Wee1 by Chk1 and 14-3-3 proteins
J Lee et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
p53 down-regulates CHK1 through p21 and the retinoblastoma protein
V Gottifredi et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast
A Lopez-Girona et al.
CURRENT BIOLOGY (2001)
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
ZJ Guo et al.
GENES & DEVELOPMENT (2000)
Mechanism of caffeine-induced checkpoint override in fission yeast
BA Moser et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Rapid destruction of human Cdc25A in response to DNA damage
N Mailand et al.
SCIENCE (2000)
The 1.7 Å crystal structure of human cell cycle checkpoint kinase Chk1:: Implications for Chk1 regulation
P Chen et al.
CELL (2000)
The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation
KR Yu et al.
NATURE CELL BIOLOGY (2000)